International Chemical Safety Cards

THEOPHYLLINE ICSC: 0678
THEOPHYLLINE
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
1,3-Dimethylxanthine
C7H8N4O2
Molecular mass: 180.2
CAS # 58-55-9
RTECS # XH3850000
ICSC # 0678
TYPES OF
HAZARD/
EXPOSURE 		ACUTE HAZARDS/
SYMPTOMS 		PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: all extinguishing agents allowed.
EXPLOSION


 
EXPOSURE
AVOID EXPOSURE OF (PREGNANT) WOMEN!
IN ALL CASES CONSULT A DOCTOR!
INHALATION (see Ingestion).
Avoid inhalation of fine dust and mist.
Fresh air, rest. Refer for medical attention.
SKIN
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
EYES
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
INGESTION Convulsions. Headache. Nausea. Vomiting. Irritability. Insomnia.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Then remove to safe place (extra personal protection: P2 filter respirator for harmful particles).
Separated from food and feedstuffs.
Do not transport with food and feedstuffs.
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0678 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

International Chemical Safety Cards

THEOPHYLLINE ICSC: 0678

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PHYSICAL STATE; APPEARANCE:
COLOURLESS, WHITE CRYSTALLINE POWDER.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including nitrogen oxides.

OCCUPATIONAL EXPOSURE LIMITS (OELs):
TLV not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the cardiovascular system, central nervous system, liver.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
PHYSICAL
PROPERTIES
 Melting point: 270-274°C
Solubility in water, g/100 ml: moderate
Octanol/water partition coefficient as log Pow: -0.02 (estimated)
ENVIRONMENTAL
DATA
N O T E S
Accurbrom, Bilordyl, Bronchorectard, Elixicon, Lasma, Sabidal, Theochram, Xanthium are trade names.
ADDITIONAL INFORMATION


ICSC: 0678 THEOPHYLLINE
© IPCS, CEC, 1993
IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.