International Chemical Safety Cards PHOSPHAMIDON ICSC: 0189 PHOSPHAMIDON 2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate 2-Chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate Dimethyl phosphate ester 2-chloro-N,N-diethyl-3-hydroxycrotonamide O,O-Dimethyl-O-(2-chloro-2-diethylcarbamoyl-1-methylvinyl) phosphate C10H19ClNO5P Molecular mass: 299.7 CAS # 13171-21-6 RTECS # TC2800000 ICSC # 0189 UN # 3018 EC # 015-022-00-6 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: alcohol-resistant foam, powder, carbon dioxide. EXPLOSION   EXPOSURE STRICT HYGIENE! INHALATION Dizziness. Sweating. Laboured breathing. Unconsciousness. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration if indicated. Refer for medical attention. SKIN MAY BE ABSORBED! (further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES Redness. Pain. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION Abdominal cramps. Diarrhoea. Nausea. Vomiting. Pupillary constriction, muscle cramps, excessive salivation (further see Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer (extra personal protection: complete protective clothing including self-contained breathing apparatus). Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Do not transport with food and feedstuffs. T+ symbol R: 24-28-40 S: (1/2-)23-36/37-45 UN Hazard Class: 6.1 UN Packing Group: II Severe marine pollutant. SEE IMPORTANT INFORMATION ON BACK ICSC: 0189 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

International Chemical Safety Cards PHOSPHAMIDON ICSC: 0189 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO YELLOW LIQUID. CHEMICAL DANGERS: The substance decomposes on heating or on burning producing highly toxic fumes including phosphorous oxides, hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium. OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes. The substance may cause effects on the nervous system , resulting in convulsions, respiratory failure and death. Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms. May cause genetic damage in humans. PHYSICAL PROPERTIES Boiling point at 0.2 kPa: 162°C Relative density (water = 1): 1.21 Solubility in water: miscible Vapour pressure, Pa at 20°C: 0.0033 Octanol/water partition coefficient as log Pow: 0.8

ENVIRONMENTAL DATA	This substance may be hazardous to the environment; special attention should be given to aquatic organisms, birds and honey bees.
N O T E S
Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Commercial product is a mixture of isomers. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Dimecron, Phosron, Pillarcron, Apamidon, Dixon and Dimenox are trade names.

ADDITIONAL INFORMATION
ICSC: 0189 PHOSPHAMIDON © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.