International Chemical Safety Cards MORPHOLINE ICSC: 0302 MORPHOLINE Tetrahydro-1,4-oxazine Diethylene oximide C4H9ON Molecular mass: 87.1 CAS # 110-91-8 RTECS # QD6475000 ICSC # 0302 UN # 2054 EC # 613-028-00-9 TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames, NO sparks, and NO smoking. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION Above 38°C explosive vapour/air mixtures may be formed. Above 38°C closed system, ventilation, and explosion-proof electrical equipment. In case of fire: keep drums, etc., cool by spraying with water.   EXPOSURE PREVENT GENERATION OF MISTS! STRICT HYGIENE! INHALATION Burning sensation. Cough. Laboured breathing. Shortness of breath. Sore throat. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention. SKIN MAY BE ABSORBED! Redness. Skin burns. Pain. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention. EYES Redness. Pain. Blurred vision. Face shield. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION Abdominal pain. Cough. Diarrhoea. Vomiting. Do not eat, drink, or smoke during work. Rinse mouth. Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place (extra personal protection: complete protective clothing including self-contained breathing apparatus). Fireproof. Separated from strong oxidants, acids. Dry. C symbol R: 10-20/21/22-34 S: 23-26 UN Haz Class: 3 UN Pack Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0302 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

International Chemical Safety Cards MORPHOLINE ICSC: 0302 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS HYGROSCOPIC LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes (nitrogen oxides). The substance is a weak base. Reacts with strong oxidants causing fire hazard. Attacks copper and its compounds. OCCUPATIONAL EXPOSURE LIMITS (OELs): TLV (as TWA): 20 ppm; 71 mg/m3 (skin) (ACGIH 1992-1993). MAK: 20 ppm; 70 mg/m3; I, H (1992). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: EFFECTS OF SHORT-TERM EXPOSURE: The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of the substance may cause lung oedema (see Notes). EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the liver and kidneys. PHYSICAL PROPERTIES Boiling point: 129°C Melting point: -5°C Relative density (water = 1): 1.0 Solubility in water: miscible Vapour pressure, kPa at 20°C: 1.06 Relative vapour density (air = 1): 3.00 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 38°C (o.c.) Auto-ignition temperature: 310°C Explosive limits, vol% in air: 1.8-11.2 Octanol/water partition coefficient as log Pow: -0.86

ENVIRONMENTAL DATA	This substance may be hazardous to the environment; special attention should be given to water organisms.
NOTES
Depending on the degree of exposure, periodic medical examination is indicated. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. The odour warning when the exposure limit value is exceeded is insufficient. NFPA Code: H 2; F 3; R 0;

ADDITIONAL INFORMATION
ICSC: 0302 MORPHOLINE © IPCS, CEC, 1993

IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.