International Chemical Safety Cards

4-METHYLPYRIDINE ICSC: 0803
4-METHYLPYRIDINE
4-Picoline
gamma-Picoline
p-Picoline
C6H7N/(C5H4N)CH3
Molecular mass: 93.1
CAS # 108-89-4
RTECS # UT5425000
ICSC # 0803
UN # 2313
EC # 613-037-00-8
TYPES OF
HAZARD/
EXPOSURE 		ACUTE HAZARDS/
SYMPTOMS 		PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 57°C explosive vapour/air mixtures may be formed.
Above 57°C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep drums, etc., cool by spraying with water.
 
EXPOSURE
PREVENT GENERATION OF MISTS!

INHALATION Burning sensation. Cough. Dizziness. Drowsiness. Headache. Laboured breathing. Nausea. Sore throat. Unconsciousness. Weakness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
SKIN MAY BE ABSORBED! Dry skin. Redness. Burning sensation. Pain. Blisters (further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
EYES Pain. Blurred vision. Severe deep burns.
Safety spectacles, face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
INGESTION Abdominal pain. Burning sensation. Diarrhoea (further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place (extra personal protection: self-contained breathing apparatus).
Fireproof. Separated from strong oxidants, acids.

T symbol
R: 10-20/22-24-36/37/38
S: 26-36-44
UN Hazard Class: 3
UN Packing Group: II
Marine pollutant.
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0803 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

International Chemical Safety Cards

4-METHYLPYRIDINE ICSC: 0803

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.




CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes (nitrogen oxides). Reacts with oxidants and strong acids.

OCCUPATIONAL EXPOSURE LIMITS (OELs):
TLV not established.
PDK (as mixture of isomers): 5 mg/m3 (USSR 1991).


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Exposure far above the OEL may result in unconsciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. The substance may have effects on the central nervous system.
PHYSICAL
PROPERTIES
 Boiling point: 144-145°C
Melting point: 3.7°C
Relative density (water = 1): 0.96
Solubility in water: miscible
Vapour pressure, kPa at 25°C: 1.3		 Relative vapour density (air = 1): 3.2
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.029
Flash point: 57°C
Explosive limits, vol% in air: 1.3-8.7
Octanol/water partition coefficient as log Pow: 1.22
ENVIRONMENTAL
DATA
NOTES
The compound turns brown if not very pure. Data are insufficiently available on the effect of this substance on human health, therefore utmost care must be taken. The relation between odour and the occupational exposure limit cannot be indicated. Also consult ICSC # 0801: 2-Methylpyridine and 0802: 3-Methylpyridine.
NFPA Code: H 2; F 2; R 0;
ADDITIONAL INFORMATION


ICSC: 0803 4-METHYLPYRIDINE
© IPCS, CEC, 1993
IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.